Stephen P. Cramer

Stephen P. Cramer

Cramer

Professor of Applied Science

Research Focus:

Structure of metal-containing molecules; high resolution x-ray fluorescence and x-ray Raman spectroscopy; soft x-ray spectroscopy and x-ray magnetic circular dichroism; EXAFS, Mo and V nitrogenase; hydrogenase and other Ni metalloproteins.

Contact Information:

Office: MS6-2100 (Berkeley Site)
Office: 3005 EU III (Davis Site)

Education:

1969-1973 Williams College, Williamstown, Massachusetts – B.A. Chemistry
1973-1977 Stanford University, Stanford, California – Ph.D. Chemistry

Professional Experience:

1977-1978 Post-Doctoral Fellow, Prof. Harry Gray, Cal Tech, Pasadena, CA
1978-1984 Research and Staff Chemist, Exxon Research, Annandale, NJ
1984-1986 Senior Staff Chemist, Exxon Research, Annandale, NJ
1985-1986 Group Head, Exxon Research, Annandale, NJ
1984-1987 Visiting Scholar, Stanford University, Stanford, CA
1986-1988 Member of Professional Staff Schlumberger-Doll Research, Ridgefield, CT
1988-90 Physicist, National Synchrotron Light Source, Upton, NY
1985-1986 Chair, SSRL Users’ Organization
1995 Visiting Professor, Massachusetts Institute of Technology, Cambridge, MA
1994-present SSRL Adjunct Professor, Stanford University, Stanford, CA
1990-present Adjunct Professor, Department of Chemistry, Louisiana State University
1991-present Senior Faculty Scientist Structural Biology Division, Lawrence Berkeley Lab, Berkeley, CA
1991- present Advanced Light Source Professor, Department of Applied Science, University of California – Davis, CA
2001 Visiting Adjunct Professor, Williams College, Williamstown, MA
2002 Visiting Professor, University of California – Berkeley, CA

Research Projects Ongoing or Completed During the Last 3 Years:

1) “Imaging with Electron Capture Isotopes and X-Ray Camera”
Principal Investigator: Stephen P. Cramer
Agency: NIGMS
Type: (R01 GM-44380) Period: December 1, 1998 thru November 30, 2002.

The goal of this project is to develop soft x-ray spectroscopy and x-ray magnetic circular dichroism as a tool for the study of metalloprotein active sites. These experiments will complement the hard x-ray experiments in the current proposal. There will be no direct overlap.

2) “Soft and Hard X-Ray Spectroscopy of Nickel Enzymes”
Principal Investigator: Stephen P. Cramer
Agency: NIH
Type: (R21 CA-87499) Period: June 1, 2000 thru May 30, 2002.

This is a project to develop a Rowland circle x-ray array spectrometer as an imaging instrument for small animal studies.

Recent Publications

  1. “X-Ray Magnetic Circular Dichroism – A Primer for Chemists”, Cramer, S. P., in Paramagnetic Resonance of Metallobiomolecules; Telser, J., Ed.; American Chemical Society: Washington, D. C., 2003; Vol. 858, pp. 358-402.
  2. “X-Ray Magnetic Circular Dichroism of Pseudomonas aeruginosa Nickel(II) Azurin”, Funk, T.; Kennepohl, P.; Di Bilio, A. J.; Wehbi, W. A.; Young, A. T.; Friedrich, S.; Arenholz, E.; Gray, H. B.; Cramer, S. P. J. Am. Chem. Soc., 2004, 126, 5859-5866.
  3. “The electronic structure of Mn in oxides, coordination complexes, and the oxygen-evolving complex of photosystem II studied by resonant inelastic X-ray scattering”, Glatzel, P.; Bergmann, U.; Yano, J.; Visser, H.; Robblee, J. H.; Gu, W.; de Groot, F. M.; Christou, G.; Pecoraro, V. L.; Cramer, S. P.; Yachandra, V. K. J. Am. Chem. Soc., 2004, 126, 9946-9959.
  4. “Normal Mode Analysis of Pyrococcus furiosus Rubredoxin via Nuclear Resonant Vibrational Spectroscopy (NRVS) and Resonance Raman Spectroscopy”, Xiao, Y.; Wang, H.; George, S. J.; Smith, M. C.; Adams, M. W. W.; Francis E. Jenney, J.; Sturhahn, W.; Alp, E. E.; Zhao, J.; Yoda, Y.; Dey, A.; Solomon, E. I.; Cramer, S. P. J. Am. Chem. Soc., 2005, 127, 14596 -14606.
  5. “Normal Mode Analysis of (FeCl4)- and (Fe2S2Cl4)2- via Vibrational Mössbauer, Resonance Raman, and FT-IR Spectroscopy”, Smith, M. C.; Xiao, Y.; Wang, H.; George, S. J.; Coucovanis, D.; Koutmos, M.; Sturhahn, W.; Alp, E. E.; Zhao, J.; Cramer, S. P. Inorg. Chem., 2005, 44, 5562-5570.
  6. “Resonant inelastic X-ray scattering (RIXS) spectroscopy at the Mn K absorption pre-edge — a direct probe of the 3d orbitals”, Glatzel, P.; Yano, J.; Bergmann, U.; Visser, H.; John H. Robblee; Gu, W.; Groot, F. M. F. d.; Cramer, S. P.; Yachandra, V. K. J. Phys. Chem. Sol., 2005, 66, 2163–2167.
  7. “How Nitrogenase Shakes – Initial Information about P-Cluster and FeMo-Cofactor Normal Modes from Nuclear Resonance Vibrational Spectroscopy (NRVS)”, Xiao, Y.; Fischer, K.; Smith, M. C.; Newton, W.; Case, D. A.; George, S. J.; Wang, H.; Sturhahn, W.; Alp, E. E.; Zhao, J.; Yoda, Y.; Cramer, S. P. J. Am. Chem. Soc., 2006, 128, 7608-7612.
  8. “The advantages of soft X-rays and cryogenic spectrometers for measuring chemical speciation by X-ray spectroscopy”, Drury, O. B.; Friedrich, S.; George, S. J.; Cramer, S. P. Nucl. Inst. Meth. A, 2006, 559, 728-730.
  9. “Observation of Terahertz Vibrations in Pyrococcus furiosus Rubredoxin via Impulsive Coherent Vibrational Spectroscopy and Nuclear Resonance Vibrational Spectroscopy – Interpretation by Molecular Mechanics”, Tan, M.-L.; Bizzarri, A. R.; Xiao, Y.; Cannistraro, S.; Ichiye, T.; Manzoni, C.; Cerullo, G.; Adams, M. W. W.; Francis E. Jenney, J.; Cramer, S. P. J. Inorg. Biochem., 2006, 101, 375-384.
  10. “Identification of a Mo-Fe-S cluster on NifEN by Mo K-edge EXAFS”, George, S. J.; Igarashi, R. Y.; Piamonteze, C.; Soboh, B.; Cramer, S. P.; Rubio, L. M. J. Am. Chem. Soc., 2007, 129, 3060-3061.

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