Professor of Applied Science
Using physical techniques to study the dynamics of biological processes at the molecular level.
Web: Research Group Web page
Office: 3009 EU III
1956 – 1960 B.S., Physics, Massachusetts Institute of Technology,
1960 – 1965 Ph.D., Physics, Columbia University,
1965 – 1966 Postdoctoral Fellow, Columbia Radiation Laboratory, New York, NY,
1966 – 1972 Postdoctoral Fellow, Research Physicist, Lawrence Livermore National Laboratory, Livermore, CA,
1972 – present Assoc. Prof., Professor, Dept. of Applied Science, UCD, Davis, CA
1998 – present Executive Committee, Graduate Group in Biophysics, UC Davis
2002 – present Associate Director for Science, Center for Biophotonics Science and Technology, UC Davis
2005 – present Chair, Designated Emphasis in Biophotonics, UC Davis
Roche Foundation Fellow (1980), AAAS Fellow, (1992), JSPS Fellow, (2000)
Molecular motors – Molecular mechanisms associated with muscle contractility, motility, and molecular motors (myosin-actin, kinesin-microtubule, DNA motors -DNA). The techniques employed include optical microscopy and spectroscopy, light scattering (dynamic and Raman), ellipsometry, optical trapping and many aspects of fluorescence microscopy (TIRF, confocal, FCS, FRET, Antibunching).
Biomineralization and biomimetics – This area covers the topics of antifreeze protein – ice as well as amino acid – calcite interfaces. The techniques used are scanning force microscopy, nuclear magnetic resonance (solution and solid state), surface-sensitive nonlinear optical spectroscopy, and molecular dynamics simulation.
Cellular signaling mechanisms – This area includes protein aggregation on membranes for the purpose of intra- and intercellular signaling for functions. We use optical and scanning microscopy methods to investigate the dynamics of organization structures on cell membranes.
Bianco, P.R., Brewer, L.R., Corzett, M., Balhorn, R., Yeh, Y. Kowalczykowski, S.C., & Baskin, R.J., Processive translocation and DNA unwinding by individual RecBCD enzyme molecules, Nature 409: 374-378, 2001.
Zepeda, S., Orme, C., & Yeh, Y. Atomic force microscope chamber for in situ studies of ice. Rev. Sci. Instru., 72:4159-4163, 2001.
Tsvetkova, N.M., Phillips, B.L., Krishnan, V.V., Feeney, R.E., Fink, W.H., Crowe, J.H., Risbud, S.H., Tablin, F. & Yeh, Y., Dynamics of antifreeze glycoproteins in the presence of ice. Biophys. J. 82:464-473, 2002.
Noy, A., Zepeda, S., Orme, C.A., Yeh, Y. & De Yoreo, J.J., Entropic barriers in nanoscale adhesion studied by variable temperature chemical force microscopy. J. Am. Chem. Soc., 125: 1356-1362, 2003.
Nguyen, D.H., Colvin, M.E., Yeh, Y., Feeney, R.E. & Fink, W.H., Intermolecular interaction studies of winter flounder antifreeze protein reveal the existence of thermally accessible binding states. Biopolymers, 75: 109-117, 2004.
Samantha Fore, Ted Laurence, Yin Yeh, Rod Balhorn, Christopher W. Hollars, Monique Cosman, Thomas Huser, Distribution analysis of the photon correlation spectroscopy of discrete numbers of dye-molecules conjugated to DNA, IEEE J. Selected Topics in Qu. Electronics, 11:873-880, 2005.
Lincoln, J.E., Boling, M, Parikh, A., Yeh, Y., Gilchrist, D.G., & Morse, L.S., Fas signaling induces apoptotic raft formation in human RPE cells that is blocked by chloresterol depletion. (In press, Investig. Ophthalmology and Vision Science, 2006)